Perlukah suplementasi DHA pada ibu hamil ?

Suplementasi DHA pada ibu hamil tidak mengurangi tingkat depresi post partum ibu maupun meningkatkan fungsi kognitif dan bahasa pada anaknya

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JAMA 304(15):1675-1683, 20 October 2010 © 2010 American Medical Association
Effect of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children
A Randomized Controlled Trial
Maria Makrides, BSc, BND, PhD; Robert A. Gibson, BSc, PhD; Andrew J. McPhee, MBBS; Lisa Yelland, BSc;Julie Quinlivan, MBBS, PhD; Philip Ryan, MBBS, BSc; and the DOMInO Investigative Team

JAMA. 2010;304(15):1675-1683. doi:10.1001/jama.2010.1507
Context  Uncertainty about the benefits of dietary docosahexaenoic acid (DHA) for pregnant women and their children exists, despite international recommendations that pregnant women increase their DHA intakes.
Objective  To determine whether increasing DHA during the last half of pregnancy will result in fewer women with highlevels of depressive symptoms and enhance the neurodevelopmental outcome of their children.
Design, Setting, and Participants  A double-blind, multicenter, randomized controlled trial (DHA to Optimize Mother Infant Outcome [DOMInO] trial) in 5 Australian maternity hospitals of 2399 women who were less than 21 weeks' gestation with singleton pregnancies and who were recruited between October 31, 2005, and January 11, 2008. Follow-up of children (n = 726) was completed December 16, 2009.
Intervention  Docosahexaenoic acid–rich fish oil capsules (providing 800 mg/d of DHA) or matched vegetable oilcapsules without DHA from study entry to birth.
Main Outcome Measures  High levels of depressive symptoms in mothers as indicated by a score of more than 12 on the Edinburgh Postnatal Depression Scale at 6 weeks or 6 months postpartum. Cognitive and language development in children as assessed by the Bayley Scales of Infant and Toddler Development, Third Edition, at 18 months.
Results  Of 2399 women enrolled, 96.7% completed the trial. The percentage of women with high levels of depressive symptoms during the first 6 months postpartum did not differ between the DHA and control groups (9.67% vs 11.19%; adjusted relative risk, 0.85; 95% confidence interval [CI], 0.70-1.02; P = .09). Mean cognitive composite scores (adjusted mean difference, 0.01; 95% CI, –1.36 to 1.37; P = .99) and mean language composite scores (adjusted mean difference, –1.42; 95% CI, –3.07 to 0.22; P = .09) of children in the DHA group did not differ from children in the control group.
Conclusion  The use of DHA-rich fish oil capsules compared with vegetable oil capsules during pregnancy did not result in lower levels of postpartum depression in mothers or improved cognitive and language development in their offspring during early childhood.