Untung Rugi Konsumsi Seafood

Para peneliti dari Harvard ingin mengetahui keuntungan dan kerugian konsumsi seafood.

Ternyata konsumsi seafood (terutama ikan yang kaya asam lemak omega-3 berupa DHA maupun EPA) sebanyak 1-2 porsi tiap minggu dapat menurunkan angka kematian penyakit jantung koroner sebesar 36%.

DHA mendukung perkembangan awal sel2 saraf, sehingga ibu hamil dan menyusui dianjurkan untuk konsumsi seafood 2 porsi tiap minggu. Kontaminasi metil-merkuri sebaliknya menghambat perkembangan sel2 saraf, namun pengaruh metil-merkuri untuk orang dewasa kurang nyata.

Dianjurkan mengkonsumsi beragam jenis seafood.

Kadar kontaminasi dioxin dan polychlorinated biphenyls terdeteksi rendah, sehingga potensi karsinogeniknya juga rendah.

Disimpulkan bahwa keuntungan konsumsi beragam seafood lebih besar dibanding efek negatifnya, termasuk untuk kelompok wanita usia subur.

Catatan untuk seafood dari perairan dengan tingkat kontaminasi lebih tinggi, kesimpulan di atas mungkin tidak berlaku.

Abstract

JAMA <http://jama.ama-assn.org/cgi/content/abstract/296/15/1885?etoc><http://jama .ama-assn.org/cgi/content/abstract/296/15/1885?etoc> 2006;296:1885-1899. Vol. 296 No. 15, October 18, 2006 © 2006 American Medical Association. Fish Intake, Contaminants, and Human Health: Evaluating the Risks and the Benefits. Dariush Mozaffarian, Eric B. Rimm.

Context Fish (finfish or shellfish) may have health benefits and also contain contaminants, resulting in confusion over the role of fish consumption in a healthy diet. Evidence Acquisition We searched MEDLINE, governmental reports, and meta-analyses, supplemented by hand reviews of references and direct investigator contacts, to identify reports published through April 2006 evaluating (1) intake of fish or fish oil and cardiovascular risk, (2) effects of methylmercury and fish oil on early neurodevelopment, (3) risks of methylmercury for cardiovascular and neurologic outcomes in adults, and (4) health risks of dioxins and polychlorinated biphenyls in fish. We concentrated on studies evaluating risk in humans, focusing on evidence, when available, from randomized trials and large prospective studies. When possible, meta-analyses were performed to characterize benefits and risks most precisely. Evidence Synthesis Modest consumption of fish (eg, 1-2 servings/wk), especially species higher in the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduces risk of coronary death by 36% (95% confidence interval, 20%-50%; P<.001) and total mortality by 17% (95% confidence interval, 0%-32%; P = .046) and may favorably affect other clinical outcomes. Intake of 250 mg/d of EPA and DHA appears sufficient for primary prevention. DHA appears beneficial for, and low-level methylmercury may adversely affect, early neurodevelopment. Women of childbearing age and nursing mothers should consume 2 seafood servings/wk, limiting intake of selected species. Health effects of low-level methylmercury in adults are not clearly established; methylmercury may modestly decrease the cardiovascular benefits of fish intake. A variety of seafood should be consumed; individuals with very high consumption (5 servings/wk) should limit intake of species highest in mercury levels. Levels of dioxins and polychlorinated biphenyls in fish are low, and potential carcinogenic and other effects are outweighed by potential benefits of fish intake and should have little impact on choices or consumption of seafood (women of childbearing age should consult regional advisories for locally caught freshwater fish). Conclusions For major health outcomes among adults, based on both the strength of the evidence and the potential magnitudes of effect, the benefits of fish intake exceed the potential risks. For women of childbearing age, benefits of modest fish intake, excepting a few selected species, also outweigh risks.

Author Affiliations: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; and Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, Mass.