Perut buncit meningkatkan risiko kematian

Dalam penelitian multisenter di Eropa terhadap 360 ribu partisipan yang di-follow-up selama hampir 10 tahun, ditemukan bahwa risiko kematian pada pria dan wanita dengan lingkar pinggang besar (the highest quintile) meningkat masing-masing 2.05 kali dan 1.78 kali. Demikian pula untuk waist-to-hip ratio besar (the highest quintile) meningkat masing-masing 1.68 dan 1.51.

 

Risiko terendah adalah yang mempunyai indeks massa tubuh <25.3 untuk pria dan <24.3 untuk wanita.

 

Kesimpulan baik general adiposity maupun abdominal adiposity berhubungan dengan risiko kematian. Sebaiknya dilakukan pengukuran lingkar pingang, waist-to-hip ratio, dan indeks massa tubuh untuk menilai risiko kematian.

 

 

 

N Engl J Med 359(20):2105-2120, 13 November 2008 © 2008 to the Massachusetts Medical Society
General and Abdominal Adiposity and Risk of Death in Europe.

T. Pischon, H. Boeing, K. Hoffmann, et al.

 

ABSTRACT

Background Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death.

Methods We examined the association of BMI, waist circumference, and waist-to-hip ratio with the risk of death among 359,387 participants from nine countries in the European Prospective Investigation into Cancer and Nutrition (EPIC). We used a Cox regression analysis, with age as the time variable, and stratified the models according to study center and age at recruitment, with further adjustment for educational level, smoking status, alcohol consumption, physical activity, and height.

Results During a mean follow-up of 9.7 years, 14,723 participants died. The lowest risks of death related to BMI were observed at a BMI of 25.3 for men and 24.3 for women. After adjustment for BMI, waist circumference and waist-to-hip ratio were strongly associated with the risk of death. Relative risks among men and women in the highest quintile of waist circumference were 2.05 (95% confidence interval [CI], 1.80 to 2.33) and 1.78 (95% CI, 1.56 to 2.04), respectively, and in the highest quintile of waist-to-hip ratio, the relative risks were 1.68 (95% CI, 1.53 to 1.84) and 1.51 (95% CI, 1.37 to 1.66), respectively. BMI remained significantly associated with the risk of death in models that included waist circumference or waist-to-hip ratio (P<0.001).

Conclusions These data suggest that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI in assessing the risk of death.