Fw: Low-carbohydrate, high-protein diet and long-term survival in a general population cohort

European Journal of Clinical Nutrition. 2007;61:575 - 581. May 2007. ©2007
Nature Publishihg Group.
Low-carbohydrate - high-protein diet and long-term survival in a general
population cohort,
A Trichopoulou, T Psaltopoulou, P Orfanos, C-C Hsieh, and D Trichopoulos

Diet rendah karbohidrat tinggi protein (RKTP) banyak digunakan untuk
menurunkan berat badan. Para ahli di Yunani ingin mengetahui hubungan diet
RKTP dengan kesehatan.

Dilakukan penelitian kohort terhadap >23.000 laki2 dan perempuan sehat
berusia 20-86 tahun.

Orang yang pola dietnya tinggi karbohidrat mempunyai risiko mortalitas yang
lebih rendah. Sebaliknya mereka yang diet tinggi protein mempunyai risiko
mortalitas lebih tinggi.

Sehingga disimpulkan bahwa diet RKTP dalam jangka panjang meningkatkan
risiko kematian.

Abstract

Objective:

We have evaluated the effects on mortality of habitual low
carbohydrate-high-protein diets that are thought to contribute to weight
control.

Design:

Cohort investigation.

Setting:

Adult Greek population.

Subjects methods:

Follow-up was performed from 1993 to 2003 in the context of the Greek
component of the European Prospective Investigation into Cancer and
nutrition. Participants were 22 944 healthy adults, whose diet was assessed
through a validated questionnaire. Participants were distributed by
increasing deciles according to protein intake or carbohydrate intake, as
well as by an additive score generated by increasing decile intake of
protein and decreasing decile intake of carbohydrates. Proportional hazards
regression was used to assess the relation between high protein, high
carbohydrate and the low carbohydrate-high protein score on the one hand and
mortality on the other.

Results:

During 113 230 persons years of follow-up, there were 455 deaths. In models
with energy adjustment, higher intake of carbohydrates was associated with
significant reduction of total mortality, whereas higher intake of protein
was associated with nonsignificant increase of total mortality (per decile,
mortality ratios 0.94 with 95% CI 0.89 -0.99, and 1.02 with 95% CI
0.98 -1.07 respectively). Even more predictive of higher mortality were high
values of the additive low carbohydrate-high protein score (per 5 units,
mortality ratio 1.22 with 95% CI 1.09 -to 1.36). Positive associations of
this score were noted with respect to both cardiovascular and cancer
mortality.

Conclusion:

Prolonged consumption of diets low in carbohydrates and high in protein is
associated with an increase in total mortality.